The Scientists Collection is comprised of individual letters and small groups of correspondence from American, British, French, and German scientists during the past three centuries. Although the content is highly varied, there is significant strength in astronomy, natural history, conchology, and geology. Among the scientists better represented in the collection are the astronomers William Radcliffe Birt, J.F.W. Herschel, and Franz Xaver von Zach; the conchologists A.D. Brown, Fred L. Button, Otto Mörch, Alfred Newton, Christian M. Poulsen, Temple Prime, Benjamin Lewis Vulliamy, and A. G. Wetherby; the physical scientists George Biddell Airy, Arnold Sommerfeld, Ferdinand R. Hassler, and Max Planck; the archaeologist Jean François Nadaillac; the philosopher William Whewell; and the naturalists Walter Henry Bates, Robert Chambers, Edme Dupuget, Robert Kaye Greville, Joseph Henry, John Stevens Henslow, John Lubbock, and Herbert Spencer.

One of the most important natural historians in nineteenth century Britain, Charles Darwin provided the first compelling mechanism to account for organismal evolutionary change. Although lacking a coherent model of heredity, Darwin's natural selection has exerted an enormous influence over the biological sciences and since the introduction of Mendelian genetics, had remained the key unifying principle in the discipline. The APS Darwin Papers are a large a valuable assemblage of Darwin's correspondence with scientific colleagues, including Charles Lyell and George J. Romanes. They are included in the print version of the Correspondence of Charles Darwin (Cambridge Univ. Press).